Covid-19 with Pre-Existing Neurological Disease

Objective: COVID-19 has varying impact on different groups of people based age, gender, race and comorbidities. Although the implications chronic pulmonary cardiovascular disease have been extensively studied, neurological remains unclear. We attempt to identify outcome challenges in patients with conditions.
 
 Methods: conducted a systematic review meta-analysis 15 studies 11,011 compare composite poor mortality between without also analyzed clinical presentations conditions. Results: found markedly higher incidence (Odds Ratio: 5.57, 95% CI: 3.81-8.12, P = 0.02) 6.47, 3.94 - 10.63, 0.008) among pre-existing disease, no significantly outcomes cerebrovascular dementia. Linear Meta-regression analysis revealed that was independent (P=0.406), hypertension (P=0.458), diabetes mellitus (P=0.512), COPD (P=0.281), advanced age (p=0.066).
 Conclusion: Patients seem develop moderate/severe more frequently, an increased rate, other They show atypical presentation SARS-CoV-2 infection. Advanced cognitive dysfunction, immunosuppression, respiratory muscle weakness might be responsible for adverse these patients.